The ex England international will feature for his country for the first time in 2 years, last featuring in November 2016 in a World Cup qualifier against Scotland.
The friendly, at Wembley on 15th November, will see donations go towards the Wayne Rooney foundation, a charity which strives to improve the lives of disadvantaged children and young people in the UK.
The game will also be called The Wayne Rooney Foundation International.
Previous charity events have included Rooney's testimonial match in 2016 featuring Everton and Manchester United, which raised £1.2m.
This will be Rooney's 120th and final cap with the game marking a farewell to England's record goalscorer. Rooney netted 53 goals in 119 apps, spanning 14 years.
Rooney will start the game on the bench and he is expected to join play, towards the end of the match which will allow supporters to show their support and appreciation to the Three Lions star.
Captaining England on 23 occasions, the former Manchester United player is England's second most capped player with Peter Shilton leading the way with 125 caps.
Rooney expressed his thoughts on Twitter: ''I am truly humbled and hugely excited to play for England at Wembley again. Winning my 120th - and final - cap will be a special moment for me."
The striker will be facing the country where he now plays. He joined Washington based MLS side DC United during the Summer where he has seen a successful last few months.
He has 12 goals in 21 apps for DC, a side he joined whilst they were bottom of the league. They rose all the way up to reach the MLS playoffs yet they were eliminated over the weekend as they lost on penalties to Columbus Crew, with Rooney missing his spot kick.
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